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Geographic tongue treated with topical tacrolimus

Masaya Ishibashi, Genichi Tojo, Masahiko Watanabe, Takahiro Tamabuchi, Takashi Masu, Setsuya Aiba

Abstract


Background: Geographic tongue, or benign migratory glossitis, is usually an asymptomatic inflammatory disorder of the tongue mucosa of unknown etiology. It is characterized by circinate, erythematous, ulcer-like lesions of the dorsum and lateral border of the tongue due to loss of filiform papillae of the tongue epithelium. Symptomatic treatments have not been evaluated rigorously.

Main observation: We describe herein two cases of adult patients with persistent and painful geographic tongue successfully treated with topical application of 0.1% tacrolimus ointment.

Conclusion: To our knowledge, this is the first report of successful treatment with topical 0.1% tacrolimus for symptomatic geographic tongue. Clinical trials are needed to confirm the efficacy and the safety of topical tacrolimus in treating geographic tongue.

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Ishibashi M, Tojo G, Watanabe M, Tamabuchi T, Masu T, Aiba S. Geographic tongue treated with topical tacrolimus. J Dermatol Case Rep. 2010; 4(4): 57-59.

Keywords


benign migratory glossitis; calcineurin inhibitors; geographic tongue; tacrolimus; treatment

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